disulphide bond

disulphide bond
The -S-S- linkage. A linkage formed between the SH groups of two cysteine moieties either within or between peptide chains. Each cysteine then becomes a half-cystine residue. -S-S- linkages stabilize, but do not determine, secondary structure in proteins. They are easily disrupted by -SH groups in an exchange reaction and are not present in cytosolic proteins (cytosol has a high concentration of glutathione that has a free -SH residue).

Dictionary of molecular biology. 2004.

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  • disulphide bond — disulphide bond. См. дисульфидная связь. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • disulphide bond — See: disulphide bridge …   Glossary of Biotechnology

  • disulphide bridge — A chemical bond between pairs of sulphur atoms that stabilizes the three dimensional structure of proteins, and hence the protein s normal function. These form particularly readily between cysteine residues in the same or different peptide… …   Glossary of Biotechnology

  • Disulfide bond — In chemistry, a disulfide bond (Br.E. disulphide bond) is a covalent bond, usually derived by the coupling of two thiol groups. The linkage is also called an SS bond or disulfide bridge. The overall connectivity is therefore R S S R. The… …   Wikipedia

  • дисульфидная связь — disulphide bond дисульфидная связь. Kовалентная связь между двумя атомами серы, входящими в молекулы цистеина <cysteine>; Д.с. стабилизируют третичную структуру полипептидных цепей. (Источник: «Англо русский толковый словарь генетических… …   Молекулярная биология и генетика. Толковый словарь.

  • Discovery and development of small molecule c-Met inhibitors — The c Met (mesenchymal epithelial transition) tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and angiogenesis.[1] c Met is a receptor tyrosine kinase,[2] which can cause a wide variety of different cancers, such… …   Wikipedia

  • Thioredoxin fold — The thioredoxin fold is a protein fold common to enzymes that catalyze disulfide bond formation and isomerization. The fold is named for the canonical example thioredoxin and is found in both prokaryotic and eukaryotic proteins. It is an example… …   Wikipedia

  • ER Oxidoreductin — 1 (Ero1) is an oxidoreductase enzyme that catalyses the formation and isomerization of protein disulfide bonds in the endoplasmic reticulum (ER) of eukaryotes.cite journal |author=Frand AR, Cuozzo JW, Kaiser CA |title=Pathways for protein… …   Wikipedia

  • протеиндисульфидизомераза — protein disulphide isomerase протеиндисульфидизомераза. Фермент, локализованный в просветах эндоплазматического ретикулюма, катализирующий образование дисульфидных связей <disulphide bond> в процессе синтеза секретируемых белков; в то же… …   Молекулярная биология и генетика. Толковый словарь.

  • Disulfidbindung — zwischen zwei Cysteinen R und R . Ausbilden einer Disulfidbindung. Eine Disulfidbrücke, Disulfidgruppe, Disulfidbindung oder Disulfidbrückenbindung …   Deutsch Wikipedia

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